Immunosuppressive sesquiterpene alkaloids from Tripterygium wilfordii

  • J Nat Prod. 2001 May;64(5):582-7. doi: 10.1021/np000504a.
H Duan  1 ,  Y Takaishi ,  H Momota ,  Y Ohmoto ,  T Taki ,  Y Jia ,  D Li
Affiliations
  • 1. Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan.
PMID: 11374948 DOI: 10.1021/np000504a
Abstract

Nine new sesquiterpene Pyridine Alkaloids [wilfornines A (1), B (2), C (3), D (4), E (5), F (8), and G (9); wilfordinines I (6) and J (7)] and six known compounds (10-15) were isolated from a clinically used extract (T(II)) of Tripterygium wilfordii. The structures of 1-9 were elucidated by spectroscopic and chemical methods. The inhibitory effects on cytokine production of 1-3 and several related compounds were evaluated. Compounds 10 and 14 showed significant inhibitory effects on cytokine production.

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