Structures of withanosides I, II, III, IV, V, VI, and VII, new withanolide glycosides, from the roots of Indian Withania somnifera DUNAL. and inhibitory activity for tachyphylaxis to clonidine in isolated guinea-pig ileum

  • Bioorg Med Chem. 2001 Jun;9(6):1499-507. doi: 10.1016/s0968-0896(01)00024-4.
H Matsuda  1 ,  T Murakami ,  A Kishi ,  M Yoshikawa
Affiliations
  • 1. Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Kyoto, Japan
PMID: 11408168 DOI: 10.1016/s0968-0896(01)00024-4
Abstract

Seven new withanolide glycosides called withanosides I, II, III, IV, V, VI, and VII were isolated from an Indian natural medicine, Ashwagandha, the roots of Indian Withania somnifera DUNAL. (Solanaceae), together with four known compounds, withaferin A, 5 alpha,20 alpha(F)(R)-dihydroxy-6 alpha,7 alpha-epoxy-1-oxowitha-2,24-dienolide, physagulin D, and coagulin Q. The structures of withanosides I, II, III, IV, V, VI, and VII were determined based on chemical and physicochemical evidence. Principal constituents, withanoside VI (10 and 30 microM) and withaferin A (10 microM), attenuated the tachyphylaxis to clonidine on electrically stimulated guinea-pig ileum in vitro.

Products