The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups

  • Bioorg Med Chem Lett. 2001 Aug 20;11(16):2189-92. doi: 10.1016/s0960-894x(01)00419-x.
J I Levin  1 ,  J Chen ,  M Du ,  M Hogan ,  S Kincaid ,  F C Nelson ,  A M Venkatesan ,  T Wehr ,  A Zask ,  J DiJoseph ,  L M Killar ,  S Skala ,  A Sung ,  M Sharr ,  C Roth ,  G Jin ,  R Cowling ,  K M Mohler ,  R A Black ,  C J March ,  J S Skotnicki
Affiliations
  • 1. Wyeth-Ayerst Research, 401 N. Middletown Rd., Pearl River, NY 10965, USA. [email protected]
PMID: 11514167 DOI: 10.1016/s0960-894x(01)00419-x
Abstract

A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, MMP-13, and TACE was prepared and evaluated. Selective inhibitors of MMP-9, MMP-13, and TACE were identified, including the potent, orally active MMP-13 Inhibitor 4p.

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