Gnetol as a potent tyrosinase inhibitor from genus Gnetum

  • Biosci Biotechnol Biochem. 2003 Mar;67(3):663-5. doi: 10.1271/bbb.67.663.
Kenji Ohguchi  1 ,  Toshiyuki Tanaka ,  Ibrahim Iliya ,  Tetsuro Ito ,  Munekazu Iinuma ,  Kenji Matsumoto ,  Yukihiro Akao ,  Yoshinori Nozawa
Affiliations
  • 1. Gifu International Institute of Biotechnology, Mitake, Kani-gun, Gifu 505-0116, Japan. [email protected]
PMID: 12723623 DOI: 10.1271/bbb.67.663
Abstract

Gnetol (2,3',5',6-tetrahydroxy-trans-stilbene), a naturally occurring compound particularly found in the genus Gnetum, had a strong inhibitory effect on murine Tyrosinase activity. Gnetol (IC50, 4.5 microM) was stronger than kojic acid (IC50, 139 microM) as a standard inhibitor for murine Tyrosinase activity. Moreover, gnetol significantly suppressed, melanin biosynthesis in murine B16 melanoma cells.

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