The anti-HBsAg (human type B hepatitis, surface antigen) and anti-HBeAg (human type B hepatitis, e antigen) C18 dibenzocyclooctadiene lignans from Kadsura matsudai and Schizandra arisanensis

  • Chem Pharm Bull (Tokyo). 2003 Nov;51(11):1233-6. doi: 10.1248/cpb.51.1233.
Ming-Der Wu  1 ,  Ray-Ling Huang ,  Li-Ming Yang Kuo ,  Chia-Cheng Hung ,  Chi-Wi Ong ,  Yao-Haur Kuo
Affiliations
  • 1. Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan.
PMID: 14600364 DOI: 10.1248/cpb.51.1233
Abstract

The C(18) dibenzocyclooctadiene Lignans including three novel schizanrin F (1), G (2), H (3), along with the known kadsurarin (4), were isolated from Kadsura matsudai. A new C(19) homolignan named schiarisanrin E (5), together with the known C(18) Lignans, gomisin B (6), G (7) and (+)-gomisin K(3) (8) were obtained from Schizandra arisanensis. Gomisin B, G and (+)-gomisin K(3) showed moderate to strong activity for antihepatitis in anti-HBsAg (human type B hepatitis, surface antigen) and/or anti-HBeAg (human type B hepatitis, e antigen) tests. The structural elucidations of new compounds 1-3 and 5 were based on two-dimensional (2D) NMR techniques including COSY, HMQC, HMBC, NOESY and CD spectra. Preliminary structure-activity relationship studies for these isolated Lignans are also discussed.

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