Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L

  • J Ethnopharmacol. 2003 Dec;89(2-3):265-70. doi: 10.1016/j.jep.2003.09.005.
Esra Küpeli  1 ,  Nurgün Erdemoğlu ,  Erdem Yeşilada ,  Bilge Sener
Affiliations
  • 1. Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 6330, Ankara, Turkey.
PMID: 14611890 DOI: 10.1016/j.jep.2003.09.005
Abstract

Four taxoids (taxusin, baccatin VI, baccatin III and 1beta-hydroxybaccatin I) and five Lignans (lariciresinol, taxiresinol, 3'-demethylisolariciresinol-9'-hydroxyisopropylether, isolariciresinol and 3-demethylisolariciresinol) were isolated from the heartwood of Taxus baccata L. (Taxaceae) growing in Turkey through chromatographic techniques. In vivo anti-inflammatory and antinociceptive activity of these compounds were investigated. All the compounds were shown to possess significant antinociceptive activity against p-benzoquinone-induced abdominal contractions, while only lignan derivatives significantly inhibited carrageenan-induced hind paw edema in mice.

Products