Heteroarylisopropylamines as MAO inhibitors

  • Bioorg Med Chem. 2005 Jul 15;13(14):4450-7. doi: 10.1016/j.bmc.2005.04.045.
Gabriel Vallejos  1 ,  Angélica Fierro ,  Marcos Caroli Rezende ,  Silvia Sepúlveda-Boza ,  Miguel Reyes-Parada
Affiliations
  • 1. Facultad de Química y Biología, Universidad de Santiago, Casilla 40, Correo 33, Santiago, Chile.
PMID: 15908219 DOI: 10.1016/j.bmc.2005.04.045
Abstract

The in vitro Monoamine Oxidase inhibitory (MAOI) activities of 11 heteroarylisopropylamines vis-à-vis MAO-A and MAO-B were described and interpreted in terms of possible interactions with the enzyme active site. Molecular dynamics simulations allowed a comparison between the most active MAO-A Inhibitor of the series, the 1-(2-benzofuryl)-2-aminopropane, and the specific, analogous MAO-A substrate serotonin.

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