Selective cyclooxygenase-2 inhibitors from Calophyllum membranaceum

  • J Nat Prod. 2005 Oct;68(10):1514-8. doi: 10.1021/np0502342.
Jian Zou  1 ,  Daozhong Jin ,  Wenliang Chen ,  Jian Wang ,  Qunfang Liu ,  Xingzu Zhu ,  Weimin Zhao
Affiliations
  • 1. Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
PMID: 16252917 DOI: 10.1021/np0502342
Abstract

Chemical investigation of the anti-inflammatory Chinese folk medicine Calophyllum membranaceum has resulted in the isolation and characterization of three new Xanthones (1-3), one new biphenyl C-glycoside (4), and one new phenylethanoid glycoside (5) along with 17 known compounds. Their structures were characterized on the basis of spectroscopic and chemical methods. Two Xanthones, 2,6-dihydroxy-1,7-dimethoxyxanthone (1) and 3,4-dihydroxyxanthone, were found to exhibit selective inhibitory activity against cyclooxygenase-2 (IC(50)=2.99 and 1.80 microM) in vitro.