Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus

  • Planta Med. 2005 Dec;71(12):1128-33. doi: 10.1055/s-2005-873169.
Haibo Li  1 ,  Changxin Zhou ,  Yunxue Pan ,  Xiaozhong Gao ,  Xiumei Wu ,  Hua Bai ,  Linfu Zhou ,  Zhi Chen ,  Shuili Zhang ,  Shuyun Shi ,  Jiali Luo ,  Juanhua Xu ,  Liurong Chen ,  Xiaoxiang Zheng ,  Yu Zhao
Affiliations
  • 1. Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China.
PMID: 16395649 DOI: 10.1055/s-2005-873169
Abstract

Nineteen compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus were tested for inhibitory effects on hepatitis B virus (HBV) and Herpes simplex virus type-1 (HSV-1). The results showed that apigenin 4'- O- alpha-rhamnopyranoside, apigenin 7- O- beta-glucopyranosyl-4'- O- alpha-rhamnopyranoside, tricin 7- O- beta-glucopyranoside, tricin, and isoscopoletin possessed inhibitory activity against HBV replication. Protocatechuyl aldehyde exhibited an inhibiting activity on HSV-1 replication. It is therefore suggested that further investigations on these bioactive compounds might be needed to discover and develop new Antiviral agents.

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