Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi

  • Chem Pharm Bull (Tokyo). 2006 Feb;54(2):265-7. doi: 10.1248/cpb.54.265.
Quan-Bin Han  1 ,  Yu-Lin Wang ,  Ling Yang ,  Ting-Fai Tso ,  Chun-Feng Qiao ,  Jing-Zheng Song ,  Li-Jia Xu ,  Shi-Lin Chen ,  Da-Jian Yang ,  Hong-Xi Xu
Affiliations
  • 1. Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine.
PMID: 16462081 DOI: 10.1248/cpb.54.265
Abstract

Thirteen Xanthones (1-13) were isolated from the resin of Garcinia hanburyi. Among them, two new compounds (namely gaudichaudic acid, and isogambogenic acid, 1, 2), and one new natural product (deoxygaudichaudione A, 3) were identified on the basis of extensive spectral evidence including detailed 2D NMR data. Ten of these Xanthones were tested for their cytotoxicities against human leukemia K562 (K562/S) and doxorubicin-resistant K562 (K562/R) cell lines, and showed similar inhibitory effects on both cell lines, suggesting that this group of polyprenylated Xanthones might not be multidrug resistance (MDR) substrates.

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