Antiparasitic activity of some xanthones and biflavonoids from the root bark of Garcinia livingstonei

  • J Nat Prod. 2006 Mar;69(3):369-72. doi: 10.1021/np050406v.
Zakaria H Mbwambo  1 ,  Modest C Kapingu ,  Mainen J Moshi ,  Francis Machumi ,  Sandra Apers ,  Paul Cos ,  Daneel Ferreira ,  Jannie P J Marais ,  Dirk Vanden Berghe ,  Louis Maes ,  Arnold Vlietinck ,  Luc Pieters
Affiliations
  • 1. Institute of Traditional Medicine, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania.
PMID: 16562837 DOI: 10.1021/np050406v
Abstract

A new biflavanoid, ent-naringeninyl-(I-3alpha,II-8)-4'-O-methylnaringenin (6), along with five known Xanthones and two known biflavonoids, was isolated from the root bark of Garcinia livingstonei collected in Tanzania. The absolute configuration of 6 was established by CD spectroscopy. This compound showed moderate activity against P. falciparum (IC(50) 6.7 microM). Antitrypanosomal activity (IC(50) 0.87 microM) was observed for 1,4,5-trihydroxy-3-(3-methylbut-2-enyl)-9H-xanthen-9-one (3). The dimeric xanthone garcilivin A (4) showed a higher and nonselective antiparasitic activity and cytotoxicity (IC(50) 2.0 microM against MRC-5 cells) than its diastereoisomer garcilivin C (5) (IC(50) 52.3 microM).