Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4

  • Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5. doi: 10.1016/j.bmcl.2006.03.020.
Jay P Powers  1 ,  Shyun Li ,  Juan C Jaen ,  Jinqian Liu ,  Nigel P C Walker ,  Zhulun Wang ,  Holger Wesche
Affiliations
  • 1. Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA. [email protected]
PMID: 16563752 DOI: 10.1016/j.bmcl.2006.03.020
Abstract

High-throughput screening of a small-molecule compound library resulted in the identification of a novel series of N-acyl 2-aminobenzimidazoles that are potent inhibitors of interleukin-1 receptor-associated kinase-4.

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