Synthesis and analgesic activity of 2-phenoxybenzoic acid and N-phenylanthranilic acid hydrazides

  • Biol Pharm Bull. 2006 Jun;29(6):1180-5. doi: 10.1248/bpb.29.1180.
Ali Almasirad  1 ,  Rohollah Hosseini ,  Hassan Jalalizadeh ,  Zohreh Rahimi-Moghaddam ,  Nazila Abaeian ,  Maryam Janafrooz ,  Mohammad Abbaspour ,  Vahid Ziaee ,  Afshin Dalvandi ,  Abbas Shafiee
Affiliations
  • 1. Department of Medicinal Chemistry, Faculty of Pharmacy, Islamic Azad University, Tehran, Iran.
PMID: 16755013 DOI: 10.1248/bpb.29.1180
Abstract

A series of 2-phenoxybenzoic acid and N-phenylanthranilic acid hydrazides were synthesized and evaluated for their analgesic activities. Several compounds were significantly more potent than mefenamic acid and diclofenac sodium in abdominal constriction and formalin tests.

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