Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand

  • Bioorg Med Chem Lett. 2006 Oct 1;16(19):5001-4. doi: 10.1016/j.bmcl.2006.07.056.
Scott E Wolkenberg  1 ,  Zhijian Zhao ,  Marianna Kapitskaya ,  Andrea L Webber ,  Konstantin Petrukhin ,  Yui Sing Tang ,  Dennis C Dean ,  George D Hartman ,  Craig W Lindsley
Affiliations
  • 1. Department of Medicinal Chemistry, Technology Enabled Synthesis Group, Merck & Co., Inc., PO Box 4, West Point, PA 19486, USA. [email protected]
PMID: 16879962 DOI: 10.1016/j.bmcl.2006.07.056
Abstract

Agonists of NR2E3 (PNR, RNR) have been identified and optimized to EC(50)< 200 nM. A tritiated analogue of one agonist was prepared to aid in the development of a binding assay.

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