Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands

  • Bioorg Med Chem Lett. 2006 Dec 15;16(24):6328-33. doi: 10.1016/j.bmcl.2006.09.011.
Alan M Warshawsky  1 ,  Charles A Alt ,  Joseph T Brozinick ,  Allen R Harkness ,  Eric D Hawkins ,  James R Henry ,  Donald P Matthews ,  Anne R Miller ,  Elizabeth A Misener ,  Chahrzad Montrose-Rafizadeh ,  Gary A Rhodes ,  Quanrong Shen ,  Jennifer A Vance ,  Uko E Udodong ,  Minmin Wang ,  Tony Y Zhang ,  Richard W Zink
Affiliations
PMID: 17005394 DOI: 10.1016/j.bmcl.2006.09.011
Abstract

PPAR ligands with varied subtype selectivity have been synthesized using an achiral aminomethyl dihydrocinnamate template. Several compounds in this series have demonstrated potent plasma glucose and triglyceride lowering capability in rodent models of Type 2 Diabetes.