Fungal metabolites of (E)-guggulsterone and their antibacterial and radical-scavenging activities

  • Chem Biodivers. 2005 Apr;2(4):516-24. doi: 10.1002/cbdv.200590033.
M Iqbal Choudhary  1 ,  S Adnan Ali Shah ,  Amtul Sami ,  Asma Ajaz ,  Farzana Shaheen ,  Atta-ur-Rahman
Affiliations
  • 1. H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. [email protected]
PMID: 17192001 DOI: 10.1002/cbdv.200590033
Abstract

Fungal transformation of (E)-guggulsterone (= (17E)-pregna-4,17-diene-3,16-dione; 1) by Rhizopus stolonifer, Fusarium lini, Cunninghamella elegans, or Gibberella fujikuroi afforded ten hydroxylated metabolites (2-11; Scheme), which were fully characterized. Compounds 4-11 have not been described yet. Some of these novel hydroxylated metabolites, as well as acetylated derivatives thereof, exhibited significant Antibacterial and radical-scavenging activities (Table 3).

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