Bioactive lignans from Peperomia duclouxii

  • J Nat Prod. 2007 Apr;70(4):544-8. doi: 10.1021/np0604533.
Na Li  1 ,  Jian-Lin Wu ,  Toshiaki Hasegawa ,  Jun-Ichi Sakai ,  Li-Ming Bai ,  Li-Yan Wang ,  Saori Kakuta ,  Yumiko Furuya ,  Hirotsugu Ogura ,  Takao Kataoka ,  Akihiro Tomida ,  Takashi Tsuruo ,  Masayoshi Ando
Affiliations
  • 1. The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China. [email protected]
PMID: 17358082 DOI: 10.1021/np0604533
Abstract

Six new Lignans (1-6), along with 14 known compounds, were obtained from Peperomia duclouxii. The new structures were elucidated mainly by the analysis of their NMR and MS data. The absolute configurations of 1-6 were determined by comparing their optical rotations or CD spectra with those of known compounds. In cytotoxic and MDR reversal cell activity assays, compound 3 showed Cancer cell growth inhibitory activity against VA-13 and HepG2 cells, with IC50 values of 5.3 and 13.2 microg/mL, and more potent effects on calcein accumulation in MDR 2780AD cells than verapamil, a positive control. Compound 6 showed anti-inflammatory activity using an ICAM-1 assay (induction of the intercellular adhesion molecule-1), stimulated by IL-1alpha and TNF-alpha.