Indole alkaloids produced by a marine fungus isolate of Penicillium janthinellum Biourge

  • J Nat Prod. 2007 Jun;70(6):906-9. doi: 10.1021/np060396d.
Olga F Smetanina  1 ,  Anatoly I Kalinovsky ,  Yuliya V Khudyakova ,  Mikhail V Pivkin ,  Pavel S Dmitrenok ,  Sergey N Fedorov ,  Hong Ji ,  Jong-Young Kwak ,  Tatyana A Kuznetsova
Affiliations
  • 1. Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok 22, Russian Federation.
PMID: 17555349 DOI: 10.1021/np060396d
Abstract

Three new Indole Alkaloids, shearinines D, E, and F (1-3), together with the known shearinine A (4) were isolated from the marine-derived strain of the fungus Penicillium janthinellum Biourge. The chemical structures of 1-4 were established by 2D NMR and HREIMS data. Shearinines A, D, and E induce Apoptosis in human leukemia HL-60 cells, and shearinine E also inhibits EGF-induced malignant transformation of JB6 P+ Cl 41 cells in a soft agar.

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