Retapamulin inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells

  • Antimicrob Agents Chemother. 2007 Sep;51(9):3385-7. doi: 10.1128/AAC.00475-07.
W Scott Champney  1 ,  Ward K Rodgers
Affiliations
  • 1. Department of Biochemistry and Molecular Biology, J. H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA. [email protected]
PMID: 17562806 DOI: 10.1128/AAC.00475-07
Abstract

Retapamulin inhibited protein biosynthesis and cell viability in methicillin-sensitive and methicillin-resistant Staphylococcus aureus organisms. A specific inhibitory effect on 50S ribosomal subunit formation was also found. Pulse-chase labeling experiments confirmed the specific inhibition of 50S subunit biogenesis. Turnover of 23S rRNA was found, with no effect on 16S rRNA amounts.

Products