Synthesis and biological evaluation of conformationally constrained analogues of the antitubercular agent ethambutol

  • Bioorg Med Chem. 2007 Sep 1;15(17):5866-76. doi: 10.1016/j.bmc.2007.05.064.
Vanessa Faugeroux  1 ,  Yves Génisson ,  Yahya Salma ,  Patricia Constant ,  Michel Baltas
Affiliations
  • 1. Laboratoire de Synthèse et Physicochimie de Molécules d'Intérêt Biologique, UMR 5068, Université Paul Sabatier, 31062 Toulouse, Cedex 9, France.
PMID: 17566744 DOI: 10.1016/j.bmc.2007.05.064
Abstract

Three (S)-prolinol-derived conformationally restricted analogues of the antitubercular agent ethambutol were prepared and tested against Mycobacterium tuberculosis.

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