Lariatins, novel anti-mycobacterial peptides with a lasso structure, produced by Rhodococcus jostii K01-B0171

  • J Antibiot (Tokyo). 2007 Jun;60(6):357-63. doi: 10.1038/ja.2007.48.
Masato Iwatsuki  1 ,  Ryuji Uchida ,  Yoichi Takakusagi ,  Atsuko Matsumoto ,  Cheng-Lin Jiang ,  Yoko Takahashi ,  Masayoshi Arai ,  Susumu Kobayashi ,  Makoto Matsumoto ,  Junji Inokoshi ,  Hiroshi Tomoda ,  Satoshi Omura
Affiliations
  • 1. The Kitasato Institute, Shirokane, Tokyo, Japan.
PMID: 17617692 DOI: 10.1038/ja.2007.48
Abstract

Two anti-mycobacterial peptides with a lasso structure, named lariatins A and B, were separated by HP-20 and ODS column chromatographies and purified by HPLC from the culture broth of Rhodococcus jostii K01-B0171, which was isolated from soil aggregates collected in Yunnan, China. Lariains A and B showed growth inhibition against Mycobacterium smegmatis with MIC values of 3.13 and 6.25 microg/ml in agar dilution method, respectively. Furthermore, lariatin A inhibited the growth of Mycobacterium tuberculosis with an MIC of 0.39 microg/ml in liquid microdilution method.

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