New pregnane glycosides from the roots of Cynanchum otophyllum

  • Steroids. 2007 Oct;72(11-12):778-86. doi: 10.1016/j.steroids.2007.06.001.
Xiao-Xia Ma  1 ,  Fang-Ting Jiang ,  Qing-Xiong Yang ,  Xiu-Hua Liu ,  Ying-Jun Zhang ,  Chong-Ren Yang
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China.
PMID: 17707872 DOI: 10.1016/j.steroids.2007.06.001
Abstract

Six new pregnane glycosides with an acyl at C-12 and a straight sugar chain at C-3, namely otophyllosides H-M (1-6), were isolated from the roots of Cynanchum otophyllum (Asclepiadaceae) collected from Eryuan County in Yunnan province of China. Their structures were characterized to be qingyangshengenin 3-O-beta-d-glucopyranosyl-(1-->4)-beta-d-glucopyranosyl-(1-->4)-beta-d-cymaropyranosyl-(1-->4)-beta-d-oleandropyranosyl-(1-->4)-beta-d-digitoxopyranoside (1), qingyangshengenin 3-O-beta-d-glucopyranosyl-(1-->4)-beta-d-oleandropyranosyl-(1-->4)-beta-d-cymaropyranosyl-(1-->4)-beta-d-digitoxopyranoside (2), qingyangshengenin 3-O-beta-d-glucopyranosyl-(1-->4)-beta-d-cymaropyranosyl-(1-->4)-beta-d-oleandropyranosyl-(1-->4)-beta-d-cymaropyranosyl-(1-->4)-beta-d-digitoxopyranoside (3), qingyangshengenin 3-O-beta-d-glucopyranosyl-(1-->4)-beta-d-thevetopyranosyl-(1-->4)-beta-d-cymaropyranosyl-(1-->4)-beta-d-digitoxopyranoside (4), caudatin 3-O-beta-d-glucopyranosyl-(1-->4)-beta-d-glucopyranosyl-(1-->4)-beta-d-cymaropyranosyl-(1-->4)-beta-d-oleandropyranosyl-(1-->4)-beta-d-cymaropyranoside (5), caudatin 3-O-beta-d-glucopyranosyl-(1-->4)-beta-d-cymaropyranosyl-(1-->4)-beta-d-oleandropyranosyl-(1-->4)-beta-d-cymaropyranosyl-(1-->4)-beta-d-cymaropyranoside (6), respectively, on the basis of detailed spectroscopic analysis and chemical method.

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