Antimitotic quinoid triterpenes from Maytenus chuchuhuasca

  • Bioorg Med Chem Lett. 2008 Feb 1;18(3):1050-2. doi: 10.1016/j.bmcl.2007.12.016.
Hiroshi Morita  1 ,  Yusuke Hirasawa ,  Akihiro Muto ,  Tadashi Yoshida ,  Setsuko Sekita ,  Osamu Shirota
Affiliations
  • 1. Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan. [email protected]
PMID: 18164197 DOI: 10.1016/j.bmcl.2007.12.016
Abstract

Four cytotoxic quinoid Triterpenes, tingenone (1), 22 beta-hydroxytingenone (2), pristimerin (3), and celastrol (4), isolated from Maytenus chuchuhuasca, potently inhibit the polymerization of tubulin.