Compounds from Kadsura heteroclita and related anti-HIV activity

  • Phytochemistry. 2008 Mar;69(5):1266-72. doi: 10.1016/j.phytochem.2007.11.019.
Jian-Xin Pu  1 ,  Liu-Meng Yang ,  Wei-Lie Xiao ,  Rong-Tao Li ,  Chun Lei ,  Xue-Mei Gao ,  Sheng-Xiong Huang ,  Sheng-Hong Li ,  Yong-Tang Zheng ,  Hao Huang ,  Han-Dong Sun
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China.
PMID: 18207206 DOI: 10.1016/j.phytochem.2007.11.019
Abstract

Phytochemical investigation of the stems of Kadsura heteroclita led to isolation of 16 compounds, including the triterpenoid named longipedlactone J (2), and two dibenzocyclooctadiene type Lignans named heteroclitin I and J (3, 4). Compounds 8-10, 14, and 15 were weakly active as anti-HIV agents, whereas compounds 6 and 12 exhibited moderate anti-HIV activity with EC50 values of 1.6 microg/mL, and 1.4 microg/mL, therapeutic index (TI) values of 52.9, and 65.9, respectively. Their structures were established by spectroscopic methods, including application of 2D NMR techniques and CD spectra.

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