Towards novel S-DABOC inhibitors: synthesis, biological investigation, and molecular modeling studies

  • Bioorg Med Chem Lett. 2008 Nov 1;18(21):5777-80. doi: 10.1016/j.bmcl.2008.09.070.
Marco Radi  1 ,  Lucilla Angeli ,  Luigi Franchi ,  Lorenzo Contemori ,  Giovanni Maga ,  Alberta Samuele ,  Samantha Zanoli ,  Mercedes Armand-Ugon ,  Emmanuel Gonzalez ,  Anuska Llano ,  Jose A Esté ,  Maurizio Botta
Affiliations
  • 1. Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via Alcide de Gasperi 2, I-53100 Siena, Italy.
PMID: 18842407 DOI: 10.1016/j.bmcl.2008.09.070
Abstract

A small family of S-DABO Cytosine analogs (S-DABOCs) has been synthesized and biologically evaluated as HIV-1 Inhibitor both on wild type (wt) and drug-resistant mutants leading to the identification of an interesting compound (5d). Molecular modeling studies have been finally performed in order to rationalize the results.