Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo

  • J Nat Prod. 2008 Nov;71(11):1911-4. doi: 10.1021/np800233q.
Hao Liang  1 ,  Baitang Lai ,  Qipeng Yuan
Affiliations
  • 1. State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, People's Republic of China.
PMID: 18855447 DOI: 10.1021/np800233q
Abstract

Sulforaphane (1), a glucosinolate-derived isothiocyanate found in the cruciferous vegetable broccoli, is considered an anticarcinogenic component. In the present study, the proliferation and Apoptosis induction in human lung adenocarcinoma LTEP-A2 cells by 1 was investigated. Compound 1 caused G(2)/M-phase arrest (p < 0.05) and increase of apoptotic cell fraction (p < 0.05) in a time- and dose-dependent manner. Intraperitoneal injection of 1 significantly inhibited growth of LTEP-A2 xenografts in nude mice, and 9 days after tumor cell implantation with 100 mg/kg intraperitoneal injection of 1, the average tumor weights in 1-treated mice was >70% lower than that of the control mice.