Antioxidant effect ofSalvia miltiorrhiza

  • Arch Pharm Res. 1997 Oct;20(5):496-500. doi: 10.1007/BF02973947.
H S Kang  1 ,  H Y Chung ,  J H Jung ,  S S Kang ,  J S Choi
Affiliations
  • 1. Department of Food and Life Science, Pukyong National University, 608-737, Pusan, Korea.
PMID: 18982497 DOI: 10.1007/BF02973947
Abstract

A strong antioxidant activity, which was measured by the radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl(DPPH) radical, was detected in the methanol extract ofSalvia miltiorrhiza Bunge (Labiatae). By activity-directed fractionation, compounds 1 and 2 were isolated as antioxidant principles ofS. miltiorrhiza. Compounds 1 and 2 were identified as dimethyl lithospermate and 3-(3,4-dihydroxyphenyl)lactamide, respectively, on the basis of spectral data. The radical scavenging effect of compounds 1 and 2 on DPPH radical exceeded that of L-ascorbic acid which is a well known antioxidant. These two compounds also showed prominent inhibitory activity against free radical generation in dichlorofluorescein (DCF) method and cytoprotective effect againstt-BHP in cultured liver cell.

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