New cytotoxic phenolic derivatives from matured fruits of Magnolia denudata

  • Biosci Biotechnol Biochem. 2009 Mar 23;73(3):726-8. doi: 10.1271/bbb.80597.
Toshiro Noshita  1 ,  Hiromasa Kiyota ,  Yumi Kidachi ,  Kazuo Ryoyama ,  Shinji Funayama ,  Ken Hanada ,  Tetsuya Murayama
Affiliations
  • 1. Department of Clinical Pharmacy, Aomori University, Kohbata, Aomori, Japan. [email protected]
PMID: 19270419 DOI: 10.1271/bbb.80597
Abstract

Magnolia species are widely cultivated in Japan as garden Plants, and have been found to contain various compounds, including Alkaloids, Terpenoids, Lignans, and neolignans. The constituents of the mature fruits of M. denudata were investigated, and two new phenolic derivatives, named denudalide and denudaquinol, were isolated and characterized, together with a known neolignan compound (denudatin A). Denudalide and denudaquinol showed cytotoxicity against the SFME and r/mHM-SFME-1 cell lines.

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