Anti-Inflammatory and antiproliferative activities of trifolirhizin, a flavonoid from Sophora flavescens roots

  • J Agric Food Chem. 2009 Jun 10;57(11):4580-5. doi: 10.1021/jf900340b.
Huiping Zhou  1 ,  Herman Lutterodt ,  Zhihong Cheng ,  Liangli Lucy Yu
Affiliations
  • 1. Department of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298, USA.
PMID: 19402641 DOI: 10.1021/jf900340b
Abstract

Trifolirhizin, a pterocarpan flavonoid, was isolated from the roots of Sophora flavescens, and its chemical structure was confirmed by (1)H and (13)C NMR and MS spectra. Its anti-inflammatory activity was examined in lipopolysaccharide (LPS)-stimulated mouse J774A.1 macrophages. Trifolirhizin not only dose-dependently inhibited LPS-induced expression of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) but also inhibited lipopolysaccharide (LPS)-induced expression of cyclooxygenase-2 (COX-2). In addition, trifolirhizin showed in vitro inhibitory effects on the growth of human A2780 ovarian and H23 lung Cancer cells. These results suggest that trifolirhizin possesses potential anti-inflammatory and Anticancer activities.

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