Phenolic glycosides from Alangium salviifolium leaves with inhibitory activity on LPS-induced NO, PGE(2), and TNF-alpha production

  • Bioorg Med Chem Lett. 2009 Aug 1;19(15):4389-93. doi: 10.1016/j.bmcl.2009.05.070.
Manh Hung Tran  1 ,  Hai Dang Nguyen ,  Jin Cheol Kim ,  Jae Sue Choi ,  Hyeong Kyu Lee ,  Byung-Sun Min
Affiliations
  • 1. College of Pharmacy, Catholic University of Daegu, Gyeongsan 712-702, Republic of Korea.
PMID: 19500975 DOI: 10.1016/j.bmcl.2009.05.070
Abstract

Three new phenolic glycosides, salviifosides A-C (13), and three known compounds salicin (4), kaempferol (5), and kaempferol 3-O-beta-d-glucopyranoside (6) were isolated from the leaves of Alangium salviifolium (L.f.) Wangerin (Alangiaceae). The structures of the new metabolites were determined on the basic of spectroscopic analyses including two dimensional NMR. The anti-inflammatory activities of new compounds (1-3) were investigated on lipopolysaccharide (LPS)-induced murine macrophage cells line, RAW 264.7. Salviifoside B (2) potentially inhibits the productions of nitric oxide (NO), prostaglandin E(2) (PGE(2)), and tumor necrosis factor-alpha (TNF-alpha).

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