Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3)

  • Bioorg Med Chem Lett. 2009 Aug 1;19(15):4059-63. doi: 10.1016/j.bmcl.2009.06.021.
Scott D Kuduk  1 ,  Ronald K Chang ,  Jenny M-C Wai ,  Christina N Di Marco ,  Victoria Cofre ,  Robert M DiPardo ,  Sean P Cook ,  Matthew J Cato ,  Aneta Jovanovska ,  Mark O Urban ,  Michael Leitl ,  Robert H Spencer ,  Stefanie A Kane ,  George D Hartman ,  Mark T Bilodeau
Affiliations
  • 1. Department of Medicinal Chemistry, Sumneytown Pike, PO Box 4, West Point, PA 19486, USA. [email protected]
PMID: 19553111 DOI: 10.1016/j.bmcl.2009.06.021
Abstract

A series of indole amidines modified at the 2-position of the indole ring were evaluated as inhibitors of Acid-Sensing Ion Channel-3 (ASIC3), a novel target for the treatment of chronic pain.

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