mu-Opioid/5-HT4 dual pharmacologically active agents-efforts towards an effective opioid analgesic with less GI and respiratory side effects (Part I)
- Bioorg Med Chem Lett. 2009 Oct 1;19(19):5679-83. doi: 10.1016/j.bmcl.2009.08.016.
Affiliations
- 1. Sepracor Inc., 84 Waterford Drive, Marlborough, MA 01752, USA. [email protected]
PMID: 19700325
DOI: 10.1016/j.bmcl.2009.08.016
Abstract
Novel compounds were prepared that united the pharmacologies of the mu-opioid tramadol with the 5-HT4 agonists metoclopramide and norcisapride. The synthesis, chiral separation and in vitro activity of the new compounds is described.
Products
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Cat. No.Product NameDescriptionTargetResearch Area
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target: 5-HT ReceptorResearch Areas: Neurological Disease