Diketopiperazines from the Cordyceps-colonizing fungus Epicoccum nigrum

  • J Nat Prod. 2009 Dec;72(12):2115-9. doi: 10.1021/np900654a.
Huijuan Guo  1 ,  Bingda Sun ,  Hao Gao ,  Xulin Chen ,  Shuchun Liu ,  Xinsheng Yao ,  Xingzhong Liu ,  Yongsheng Che
Affiliations
  • 1. Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
PMID: 19919067 DOI: 10.1021/np900654a
Abstract

New diketopiperazines, epicoccins E-H (1-4) and diphenylalazines A (5) and B (6), have been isolated from the solid-substrate fermentation culture of the Cordyceps-colonizing fungus Epicoccum nigrum. The structures of 1-6 were determined primarily by NMR experiments, and the structure of 1 was confirmed by X-ray crystallography. The absolute configurations of 3 and 5 were assigned using the modified Mosher (3) and Marfey's (5) methods, respectively. Compounds 3-5 showed inhibitory effects on HIV-1 replication in C8166 cells.