Production of a new type of amidepsine with a sugar moiety by static fermentation of Humicola sp. FO-2942

  • J Antibiot (Tokyo). 2010 Jan;63(1):9-16. doi: 10.1038/ja.2009.110.
Junji Inokoshi  1 ,  Yoichi Takagi ,  Ryuji Uchida ,  Rokuro Masuma ,  Satoshi Omura ,  Hiroshi Tomoda
Affiliations
  • 1. Graduate School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
PMID: 19942946 DOI: 10.1038/ja.2009.110
Abstract

Static fermentation of amidepsine-producing fungus Humicola sp. FO-2942 led to the production of six new amidepsines, including a new type of glycosylated congener. Non-glycosylated amidepsine J inhibited both human diacylglycerol acyltransferases 1 (DGAT1) and DGAT2 with the same IC(50) value of 40 muM, whereas glycosylated amidepsines F to I showed very weak inhibitory activity against DGAT1 and DGAT2.

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