In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones

  • Bioorg Med Chem Lett. 2010 Jan 1;20(1):100-3. doi: 10.1016/j.bmcl.2009.11.033.
José C Aponte  1 ,  Denis Castillo ,  Yannick Estevez ,  German Gonzalez ,  Jorge Arevalo ,  Gerald B Hammond ,  Michel Sauvain
Affiliations
  • 1. Department of Chemistry, University of Louisville, KY 40292, USA.
PMID: 19962891 DOI: 10.1016/j.bmcl.2009.11.033
Abstract

The in vitro screening of 43 polysubstituted Chalcones against Leishmania amazonensis axenic amastigotes, led to the evaluation of 9 of them in a macrophage-infected model with the two Other most infectious Leishmania species prevalent in Peru (L. braziliensis and L. peruviana). The five most active and selective Chalcones were studied in vivo, resulting on the identification of two Chalcones with high reduction Parasite burden percentages.