Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent

  • Org Biomol Chem. 2010 Mar 21;8(6):1293-5. doi: 10.1039/b926217b.
Jiahui Zheng  1 ,  Xiaoqian Liu ,  Qing Yuan ,  Yoon-Joo Shin ,  Daekyu Sun ,  Yixin Lu
Affiliations
  • 1. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Republic of Singapore.
PMID: 20204198 DOI: 10.1039/b926217b
Abstract

Aminomethylated Beaucage's reagent 1 was found to be more potent than 3H-1,2-benzodithiol-3-one 1,1-dioxide (Beaucage's reagent) in causing DNA cleavage. The current study demonstrated the importance of the amino functionality in enhancing DNA-cleaving activities, and such findings may facilitate development of novel sulfur-containing DNA-cleaving molecules in Cancer therapy.

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