Pellitorine, a potential anti-cancer lead compound against HL6 and MCT-7 cell lines and microbial transformation of piperine from Piper Nigrum

  • Molecules. 2010 Apr 5;15(4):2398-404. doi: 10.3390/molecules15042398.
Gwendoline Cheng Lian Ee  1 ,  Chyi Meei Lim ,  Mawardi Rahmani ,  Khozirah Shaari ,  Choon Fah Joseph Bong
Affiliations
  • 1. Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia. [email protected]
PMID: 20428051 DOI: 10.3390/molecules15042398
Abstract

Pellitorine (1), which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cell lines. Microbial transformation of piperine (2) gave a new compound 5-[3,4-(methylenedioxy)phenyl]-pent-2-ene piperidine (3). Two Other Alkaloids were also found from Piper nigrum. They are (E)-1-[3',4'-(methylenedioxy)cinnamoyl]piperidine (4) and 2,4-tetradecadienoic acid isobutyl amide (5). These compounds were isolated using chromatographic methods and their structures were elucidated using MS, IR and NMR techniques.

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