Parishin C attenuates phencyclidine-induced schizophrenia-like psychosis in mice: involvements of 5-HT1A receptor

  • J Pharmacol Sci. 2010;113(4):404-8. doi: 10.1254/jphs.10040sc.
Eun-Joo Shin  1 ,  Wan Kyunn Whang ,  Sungun Kim ,  Jae-Hyung Bach ,  Jin-Man Kim ,  Xuan-Khanh Thi Nguyen ,  Thuy-Ty Lan Nguyen ,  Bae Dong Jung ,  Kiyofumi Yamada ,  Toshitaka Nabeshima ,  Hyoung-Chun Kim
Affiliations
  • 1. Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, Korea.
PMID: 20644336 DOI: 10.1254/jphs.10040sc
Abstract

Parishin C, a major component of Gastrodia elata BLUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT(1A) receptor is an important therapeutic target of Schizophrenia, we examined whether parishin C affects phencyclidine-induced abnormal behaviors in mice. Phencyclidine-induced abnormal behaviors were significantly ameliorated by parishin C. These effects were reversed by WAY 100635, a 5HT(1A)-receptor antagonist. Consistently, parishin C showed high affinity at 5-HT(1A) receptor as well as a 5-HT(1A)-agonist activity in a 8-OH-DPAT-stimulated [(35)S]GTP-gammaS binding assay. Our results suggest that the antipsychotic effects of parishin C require activation of 5-HT(1A) receptors.

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