Inhibitory activity of Plantago major L. on angiotensin I-converting enzyme

  • Arch Pharm Res. 2011 Mar;34(3):419-23. doi: 10.1007/s12272-011-0309-7.
Nguyen Xuan Nhiem  1 ,  Bui Huu Tai ,  Phan Van Kiem ,  Chau Van Minh ,  Nguyen Xuan Cuong ,  Nguyen Huu Tung ,  Vu Kim Thu ,  Trinh Nam Trung ,  Hoang Le Tuan Anh ,  Sung-Hoon Jo ,  Hae-Dong Jang ,  Young-In Kwon ,  Young Ho Kim
Affiliations
  • 1. College of Pharmacy, Chungnam National University, Daejeon, Korea.
PMID: 21547673 DOI: 10.1007/s12272-011-0309-7
Abstract

Eight compounds were isolated from methanol extract of Plantago major L. leaves and investigated for their ability to inhibit angiotensin I-converting enzyme activity. Among them, compound 1 showed the most potent inhibition with rate of 28.06 ± 0.21% at a concentration of 100 μM. Compounds 2 and 8 exhibited weak activities. These results suggest that compound 1 might contribute to the ability of P. major to inhibit the activity of angiotensin I- converting enzyme.

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