Bioactive sulfoximines: syntheses and properties of Vioxx analogs

  • Bioorg Med Chem Lett. 2011 Aug 15;21(16):4888-90. doi: 10.1016/j.bmcl.2011.06.029.
Seong Jun Park  1 ,  Helmut Buschmann ,  Carsten Bolm
Affiliations
  • 1. Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52056 Aachen, Germany.
PMID: 21752640 DOI: 10.1016/j.bmcl.2011.06.029
Abstract

The syntheses and biological profiles of sulfoximine-based Vioxx analogs 2 are described. Interesting data have been obtained for 2a, which shows a selective COX-2 inhibition (albeit not as strong as Vioxx itself) exhibiting reduced hERG activity compare to the parent sulfone Vioxx (1).