Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M

  • Angew Chem Int Ed Engl. 2011 Oct 10;50(42):9838-42. doi: 10.1002/anie.201102967.
Marion Rusch  1 ,  Tobias J Zimmermann ,  Marco Bürger ,  Frank J Dekker ,  Kristina Görmer ,  Gemma Triola ,  Andreas Brockmeyer ,  Petra Janning ,  Thomas Böttcher ,  Stephan A Sieber ,  Ingrid R Vetter ,  Christian Hedberg ,  Herbert Waldmann
Affiliations
  • 1. Max-Planck-Institut für Molekulare Physiologie, Abt. Chemische Biologie, Dortmund, Germany.
PMID: 21905186 DOI: 10.1002/anie.201102967
Abstract

Finding the target: activity-based proteomic profiling probes based on the depalmitoylation inhibitors palmostatin B and M have been synthesized and were found to target acyl protein thioesterase 1 (APT1) and 2 (APT2) in cells.

Products