Synthesis of novel derivatives of esculentoside A and its aglycone phytolaccagenin, and evaluation of their haemolytic activity and inhibition of lipopolysaccharide-induced nitric oxide production

  • Chem Biodivers. 2011 Oct;8(10):1833-52. doi: 10.1002/cbdv.201000339.
Wei Gong  1 ,  Zhihui Jiang ,  Peng Sun ,  Ling Li ,  Yongsheng Jin ,  Lucheng Shao ,  Wen Zhang ,  Baoshu Liu ,  Hongwei Zhang ,  Hua Tang ,  Yufeng Chen ,  Yanghua Yi ,  Dazhi Zhang
Affiliations
  • 1. School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, P. R. China.
PMID: 22006712 DOI: 10.1002/cbdv.201000339
Abstract

A series of 46 compounds derived from esculentoside A and its aglycone were synthesized and characterized. The effect of these compounds on lipopolysaccharide (LPS)-induced NO production, haemolytic activity, and cell viability was evaluated. Structure-activity relationship was established by comparing the derivatives of esculentoside A with its aglycone derivatives. Both the aglycone and its derivatives showed higher inhibitory effects on LPS-induced NO production, and lower haemolytic activities than esculentoside A and its derivatives.

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