Two new imidazolone-containing alkaloids and further metabolites from the ascomycete fungus Tricladium sp

  • Chem Biodivers. 2011 Oct;8(10):1914-20. doi: 10.1002/cbdv.201000372.
Xianwei Zou  1 ,  Shuchun Liu ,  Zhihui Zheng ,  Hua Zhang ,  Xulin Chen ,  Xingzhong Liu ,  Erwei Li
Affiliations
  • 1. Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, P. R. China.
PMID: 22006720 DOI: 10.1002/cbdv.201000372
Abstract

Tricladins A and B (1 and 2, resp.), new imidazolone-containing Alkaloids, together with five known metabolites, bacillamides A, B (3 and 4, resp.), 20-hydroxyaflavinine (5), N-(2-phenylethyl)acetamide (6), and N(b)-acetyltryptamine (7), have been isolated from the crude extract of the ascomycete fungus Tricladium sp. The structures of 1 and 2 were elucidated primarily by NMR and MS methods. Compound 2 showed marginal cytotoxicity against MDA-MB-231 human breast Cancer cells, whereas the known metabolite 4 displayed an inhibitory effect on HIV-1 replication in C8166 cells.

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