Chemical constituents of Euphorbia tangutica

  • Nat Prod Res. 2012;26(24):2309-15. doi: 10.1080/14786419.2012.668686.
Ben-Yin Zhang  1 ,  Huan Wang ,  Xiao-Dong Luo ,  Zhi-Zhi Du ,  Hai-Feng Wu ,  Jian-Wei Shen ,  Xiao-feng Zhang
Affiliations
  • 1. Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China.
PMID: 22424102 DOI: 10.1080/14786419.2012.668686
Abstract

Sixteen known compounds isolated from the whole Plants of Euphorbia tangutica, including phorbol-13-actate (1) previously synthesised and obtained from a natural source for the first time, were evaluated in vitro against a panel of human Cancer cell lines using the MTT method. Among them, ergosterol (6) exhibited significant cytotoxic activity against HL-60 cell line with an IC(50) value of 3.3 µM, and 3β,5α-dihydroxy-15β-cinnamoyloxy-14-oxolathyra-6 Z,12 E-diene (7) also displayed moderate activity.

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