Steroidal saponins from Fritillaria pallidiflora Schrenk

  • Fitoterapia. 2012 Jun;83(4):785-94. doi: 10.1016/j.fitote.2012.03.008.
Shuo Shen  1 ,  Guoyu Li ,  Jian Huang ,  Chaojun Chen ,  Bu Ren ,  Ga Lu ,  Yong Tan ,  Jiaxu Zhang ,  Xian Li ,  Jinhui Wang
Affiliations
  • 1. School of Traditional Chinese Materia Medica 49#, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China.
PMID: 22450263 DOI: 10.1016/j.fitote.2012.03.008
Abstract

Five new steroidal saponins, Pallidifloside D (1), Pallidifloside E (2), Pallidifloside G (5), Pallidifloside H (6) and Pallidifloside I (7), together with seven Other steroidal saponins (3, 4, 8-12) were isolated from the dry bulbs of Fritillaria pallidiflora Schrenk. Their structures were established by spectroscopic techniques (IR, MS, 1D and 2D NMR) and chemical means. The isolated steroidal saponins were evaluated for cyotoxic activity against human C6 brain gliomas and Hela cervix Cancer cell lines using MTT assays. Compounds 1, 10, 11, 12 showed cytotoxicity against C6 and Hela cell lines with IC(50) values in the range of 5.1-75.8μM.

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