β-Amyrin acetate and β-amyrin palmitate as antidyslipidemic agents from Wrightia tomentosa leaves

  • Phytomedicine. 2012 Jun 15;19(8-9):682-5. doi: 10.1016/j.phymed.2012.03.013.
Ranjani Maurya  1 ,  Anuj Srivastava ,  Priyanka Shah ,  Mohammad Imran Siddiqi ,  S M Rajendran ,  Anju Puri ,  Prem P Yadav
Affiliations
  • 1. Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226001, India.
PMID: 22541636 DOI: 10.1016/j.phymed.2012.03.013
Abstract

The ethanolic extract and fractions of Wrightia tomentosa Roem. & Schult (Apocynaceae) leaves were tested in vivo for their antidyslipidemic activity in high fat diet (HFD) induced dyslipidemic hamsters. Activity guided isolation resulted in identification of antidyslipidemic compounds β-AA and β-AP. Compounds β-AA and β-AP decrease the levels of LDL by 36% and 44%, and increase the HDL-C/TC ratio by 49% and 28%, respectively, at a dose of 10mg/kg. In addition, the isolated compounds β-AA and β-AP showed significant HMG-CoA-reductase inhibition, which was further established by docking studies.

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