Wake promoting agents: search for next generation modafinil, lessons learned: part III

  • Bioorg Med Chem Lett. 2012 Jun 1;22(11):3751-3. doi: 10.1016/j.bmcl.2012.04.031.
Derek Dunn  1 ,  Greg Hostetler ,  Mohamed Iqbal ,  Val R Marcy ,  Yin Guo Lin ,  Bruce Jones ,  Lisa D Aimone ,  John Gruner ,  Mark A Ator ,  Edward R Bacon ,  Sankar Chatterjee
Affiliations
  • 1. Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA.
PMID: 22546675 DOI: 10.1016/j.bmcl.2012.04.031
Abstract

In searching for a next generation molecule to the novel wake promoting agent modafinil (compound 1), a series of fluorene-derived wakefulness enhancing agents were developed and evaluated in rat. Extensive pharmacokinetic studies of a potent member of the series (compound 15) revealed that the wake promotion activity of the analog was likely due to an active metabolite (compound 3).

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