Trigohowilols A-G, degraded diterpenoids from the stems of Trigonostemon howii

  • J Nat Prod. 2012 Nov 26;75(11):1962-6. doi: 10.1021/np3006315.
Gui-Hua Tang  1 ,  Yu Zhang ,  Chun-Mao Yuan ,  Yan Li ,  Yu-Cheng Gu ,  Ying-Tong Di ,  Yue-Hu Wang ,  Guo-Ying Zuo ,  Shi-Fei Li ,  Shun-Lin Li ,  Hong-Ping He ,  Xiao-Jiang Hao
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan, People's Republic of China.
PMID: 23148674 DOI: 10.1021/np3006315
Abstract

Two new degraded Diterpenoids, trigohowilols A (1) and B (2), four new heterodimers, trigohowilols C-F (3-6), one new homodimer, trigohowilol G (7), and three known degraded Diterpenoids (8-10) were isolated from the methanol extract of the stems of Trigonostemon howii. Compounds 1-7 were evaluated for their cytotoxic activity against five human tumor cell lines by an MTT assay, and trigohowilols E (5) and F (6) exhibited inhibitory activity with IC50 values ranging from 2.33 to 12.57 μM. Moreover, compounds 1-6 showed weak antimicrobial activities (MIC values: 6.25-25 μg/mL) against Staphylococcus aureus, Pseudomonas aeruginosa, MRSA 92(#), and MRSA 98(#) using a 2-fold dilution method.

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