Lanostane triterpenes from cultures of the Basidiomycete Ganoderma orbiforme BCC 22324

  • Phytochemistry. 2013 Mar;87:133-9. doi: 10.1016/j.phytochem.2012.11.022.
Masahiko Isaka  1 ,  Panida Chinthanom ,  Surisa Kongthong ,  Kitlada Srichomthong ,  Rattaket Choeyklin
Affiliations
  • 1. National Center for Genetic Engineering and Biotechnology (BIOTEC), Klong Luang, Pathumthani 12120, Thailand. [email protected]
PMID: 23280041 DOI: 10.1016/j.phytochem.2012.11.022
Abstract

Seven lanostane triterpenoids, ganorbiformins A-G, together with twelve known compounds, were isolated from cultures of the mushroom fungus Ganoderma orbiforme BCC 22324. Ganorbiformin A is an unusual rearranged analog, whereas the other compounds share the same lanostane skeleton with known ganoderic acids. The C-3 epimer of ganoderic acid T also exhibited significant antimycobacterial activity against Mycobacterium Tuberculosis H37Ra (MIC 1.3 μM).

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