Dibenzocyclooctadiene lignans and norlignans from fruits of Schisandra wilsoniana

  • J Nat Prod. 2013 Feb 22;76(2):250-5. doi: 10.1021/np300745q.
Guang-Yu Yang  1 ,  Rui-Rui Wang ,  Huai-Xue Mu ,  Yin-Ke Li ,  Xiao-Nian Li ,  Liu-Meng Yang ,  Yong-Tang Zheng ,  Wei-Lie Xiao ,  Han-Dong Sun
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
PMID: 23327759 DOI: 10.1021/np300745q
Abstract

Seven new dibenzocyclooctadiene Lignans, marlignans M-S (1-7), four new norlignans, marphenols C-F (8-11), and 21 known compounds (12-32) were isolated from the fruits of Schisandra wilsoniana. The structures of 1-11 were elucidated by spectroscopic methods including 1D- and 2D-NMR techniques and CD experiments. Compounds 1-11 were evaluated for their anti-HIV activities and showed EC(50) values in the range 2.97-6.18 μg/mL and therapeutic index values of 5.33-29.13.